Metal as a Carrier for Active Ligands

In order to target drug delivery, it is very important to study the distribution of the drug within the body. For example radiolabelling of the anticancer complex [Ru (r 6-fhiorene)Cl(en)]PF6 with the (3-emitter 106Ru (half-life = 1.01 y) has allowed its biodistribution to be studied 0.25 h post i.v. injection at a dose of 25 mg kg-1, 106Ru is well distributed throughout the tissues of a rat [155]. 

Various other strategies for investigating biodistributions of metallodrugs are being developed by different groups. 

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