Metabolite Profiling and Structure Determination

Many alkaloids are used therapeutically, or are being developed for therapeutic use, for illness in humans. The specific and rapid analysis of such compounds and their metabolites in human plasma can be an important aspect of managing treatment regimes. 

LC-MS/MS Approaches to the Identification/Structural Elucidation of Alkaloid Drug Metabolites 

Even with the advent of powerful techniques such as HPLC-NMR [18], LC-MS techniques can offer significant insight into the structure of eluted compounds and can be used to search for compounds/metabolites that are very specifically related to the target compound. 

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