Metabolism of glycerol

Metabolism of Glycerol Glycerol obtained from the breakdown of fat is metabolized by conversion to dihydroxy-acetone phosphate, a glycolytic intermediate, in two enzyme-catalyzed reactions. Propose a reaction sequence for glycerol metabolism. On which known enzyme-catalyzed reactions is your proposal based Write the net equation for the conversion of glycerol to pyruvate according to your scheme. 

Figure 7.1. Mechanism of uptake and initial enzymatic reactions in the microbial metabolism of glycerol (G). Note The gene products GlpF, GlpK, GlpD correspond to a glycerol facilitator protein, glycerol kinase, and glycerol 3-phosphate dehydrogenase, respectively.

Schutz, H., Radler, F. (1984b). Propanediol-1,2-dehydratase and metabolism of glycerol of Lactobacillus brevis. Arch. Microbiol., 139, 366-370. 

Nguyen, N.H., Brathe, A., Hassel, B. (2003). Neuronal uptake and metabolism of glycerol and the neuronal expression of mitochondrial glycerol-3-phosphate dehydrogenase. J. Neurochem. 85 831-42. 

During metabolism of glycerol trinitrate by Phanerochaete chryso-sporium (Servent et al. 1991). 

It has been used to elucidate the unexpected complexity of an apparently straightforward metabolic pathway the metabolism of glycerol trinitrate by Phanerochaete chrysosporium does not proceed by simple hydrolysis to nitrate and glycerol, but involves formation of nitric oxide bound to both nonheme and heme proteins (Servent et al. 1991). 

FIGURE 14.4 Metabolic pathway depicting oxidative metabolism of glycerol (Ashok et ah, 2011 Kumar et al., 2012). 

Sobolov M, Smiley FA. (1960). Metabolism of glycerol by an acrolein-forming Lactobacillus. J Bacterial, 79, 261-266. 

Fig. 17.1. Metabolism of glycerol. 17.i, Glycerol kinase cGPDH (NAD)y cytoplasmic NAD-linked glycerol-3-phosphate dehydrogenase mGPDH (FAD), mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase. Dihydroxyacetone-phosphate is an intermediate in the glycolytic pathway as well as a precursor for plasmalogens...

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