Metabolism glucocorticoids affecting

The answer is e. (Katzung, p 672. Hardman, pp 1477—1978.) Fludrocortisone is a synthetic steroid compound that exhibits profound mineralo-corticoid activity and some glucocorticoid activity Electrolyte and water metabolisms are affected by the administration of this compound. Fludrocortisone promotes the reabsorption of Na and the urinary excretion of K and hydrogen ions in the collecting duct of the nephron. The drug is indicated for mineralocorticoid replacement therapy in primary" adrenal insufficiency... 

Corticosteroids are synthesized in the adrenal cortex under the influence of ACTH. Glucocorticoids affect the metabolism of carbohydrates, proteins, fats, calcium and electrolytes. 

ACTH is a hormone released by the anterior pituitary gland that influences the glucocorticoids that are secreted by the adrenal gland. Glucocorticoids affect carbohydrate, protein, and fat metabolism in addition to muscle and blood cell activity. 

Several drugs are known to affect calcium metabolism and to Induce calcium loss (42). Amongst these are the use of glucocorticoids and thyroid extract. The use of both of these drugs can lead to the development of osteoporosis. It Is less well known that several other... 

A large amount of clinical data is available on some of the common anti-inflammatory drugs such as glucocorticoids and NSAIDs. Coupling of these drugs to drug carriers may favourably affect kinetics and metabolism, thereby improving effectiveness and safety. So,... 

Glucocorticoids accomplish this paradox by affecting the metabolism of glucose, fat, and protein (see Figure 29-4). Cortisol facilitates the breakdown of muscle into amino acids and lipids into free fatty acids, which can be transported to the liver to form... 

Glucocorticoid The general class of steroid agents that affect glucose metabolism and are used pharmacologically to decrease inflammation and suppress the immune system. Principle examples include cortisol and corticosterone. 

Steroid hormones (Section 21.8) are produced by the adrenal cortex and the gonads (testes in males, ovaries in females). The adrenocortical hormones include glucocorticoids, which affect carbohydrate metabolism, modulate inflammatory reactions, and are involved in reactions to stress. The mineralocorticoids control the level of excretion of water and salt by the kidneys. If the adrenal cortex does not function adequately, one result is Addison s disease, characterized by hypoglycemia, weakness, and increased susceptibility to stress. This disease is eventually fatal unless it is treated by administration of mineralocorticoids and glucocorticoids to make up for what is missing. The opposite condition, hyperfunction of the adrenal cortex, is frequently caused by a tumor of the adrenal cortex or of the... 

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