Metabolism, enzymes involved

These results implicate BHT as having a role in the activation, initiation or early promotional phase of DMBA-induced chemical carcinogenesis. A definite possibility is that it may require this period of time to allow for the induction of specific metabolic enzymes involved in the handling of DMBA. This time may be required for the attainment of sufficient levels in the tissues to allow effectiveness as an inhibitor. Further studies are certainly needed to narrow the wide range of possibilities. 

Thus, it appears that the activating effect exerted by the benzodiazepine alkaloids rests on a specific property of the primary metabolic enzymes involved in the biosynthesis of benzodiazepine precursors and present during the phase of alkaloid formation. If this effect would also occur in vivo (as suggested by the above characteristics), it would serve the coordination of precursor (and alkaloid) biosynthesis within a far-reaching feedback mechanism. Such a regulatory circuit... 

Shimada, T. (2006) Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons. Drug Metab. Pharmacokinet. 21, 257-276. 

Rathi, S.S., J.K. Grover, and V. Vats. 2002. The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Phytother. Res. 16(3) 236-243. 

Recently, significant progress has been made in the development of software for the prediction of drug metabolites and the automated identification of metabolite peaks from the complex mixtures. The next step, automated assignment of biotransformations and fragment ions, will be a major focus for scientists involved in drug metabolism studies. In addition, the attempts will be made in the development of in silico tools to predict the rate of metabolism and drug metabolism enzymes involved in the metabolism. 

Isothiocyanates as Inducers of Phase II Drug-Metabolizing Enzyme Involvement of Cellular Redox... 

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