Polyhydroxyalkanoate metabolic pathways

Figure 7.7 Common metabolic pathways that are involved in the biosynthesis of PHA in microorganisms. FabC malonyl-CoA acyl carrier protein (ACP) transcylase, FabD malonyl-CoA-ACP transacylase, FabG 3-ketoacyl-CoA reductase, PhaA P-ketothiolase, PhaB NAOH-dependent acetoacetyl-CoA reductase, PhaC polyhydroxyalkanoates synthase, PhaG 3-hydroxyacyl-ACP GoA transferase, PhaJ (R)-enoyl-GoA hydratase and TCA tricarboxylic acid...

Jendrossek D, Backhaus M, Andermann M (1995) Characterization of the Comamonas sp. poly(3-hydroxybutyrate) (PHB) depolymerase and of its structural gene. Can J Microbiol 41 160-169 Jendrossek D, Schirmer A, Schlegel HG (1996) Biodegradation of polyhydroxyalkanoic adds. Appl Microbiol Biotechnol 46 451—463 John ME, Keller G (1996) Metabolic pathway engineering in cotton biosynthesis of polyhydroxybutyrate in fiber cells. Proc Natl Acad Sd USA 93 12768-12773... 

Steinbuchel, A. and Lutke-Eversloh, T. 2003. Metabolic engineering and pathway construction for biotechnological production of relevant polyhydroxyalkanoates in microorganisms. Biochemical Engineering Journal 16 81-96. 

Steinbtichel, A. (2001) Perspedives for biotechnological production and utilization of biopolymers metabolic engineering of polyhydroxyalkanoate biosynthesis pathways as a successful example. Macromol. Biosci., 1,1-24. 

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