Topological network analysis metabolic modeling

We may model complex systems by top-down or bottom-up approaches. In the top-down approach, we describe the components from the systemic behavior of the actual system. For example, from the flow balance analysis in a steady-state bacterium, we learn the input and output flows, topology of the network, and the rates of maty metabolic reactions. 

Another two key concepts in metabolic engineering are metabolic pathway analysis and metabolic pathway modeling. The former is used for assessing inherent network properties in the complete biochemical reaction networks. It involves identification of the metabolic network structure (or pathway topology), quantification of the fluxes through the branches of the metabolic network, and identification of the control structures within the metabolic network. 

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