Mesylate Drops

Heat sufficient quantity of item 6 to 95 °C and hold for 1 hour. Begin bubbling nitrogen for 1 hour cool slowly to 22°C while continuing to bubble nitrogen. 

In another suitable glass-lined or stainless-steel container, charge glycerin. 

In another stainless-steel container, charge alcohol and bubble it with nitrogen for more than 2 hours. 

Check oxygen levels in step 1 to less than 1.00 ppm. 

Flush a suitable tank with nitrogen and transfer approximately 700 mL of purified water from step above and begin bubbling nitrogen. 

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Sultana, Y., Aqil, M., and Ali, A. (2006), Ion-activated, Gelrite-based in situ ophthalmic gels of pefloxacin mesylate Comparison with conventional eye drops, Drug Deliv., 13(3), 215-219. 

A 0.1 mgtal solution of pergolide mesylate is prepared in 2.5 N sulfuric acid. The addition of 1 ml of a p-dimethylaminobenzaldehyde TS and 3 drops of ferric chloride TS to 2 ml of the pergolide mesylate solution results in the immediate formation of a dark purplish blue colored solution (the control solution remains a pale yellow solution). 

Preparation of the Living" Polystyrene. 18 g of the living polymer was prepared by standard anionic polymerization using n-butyl lithium. The reaction was carried out by the drop wise addition of 20 ml of styrene to 5 ml of the initiator solution in 150 ml of neat THF at -78 C. The styrene drip was adjusted to take approximately 30 min for completion and then the reaction was allowed to stir for two hours before the grafting reaction with mesylated lignin was carried out. The number average molecular weight of the polystyrene, as determined by HPSEC, was 9500 with polydispersity of 1.2. 

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