Address-message concept

Portoghese PS, Sultana M, Nagase H, Takemori AE. Application of the message-address concept in the design of highly potent and selective nonpeptide 6 opioid receptor antagonists. J Med Chem 1988 31 281-282. 

Rational design of nonpeptide 5 opioid ligands - the message address concept... 

Extension of the message address concept to nonaromatic moieties... 

Figure 1 A cartoon of the message-address concept as a basis for the selectivity of a family of sychnologically organized peptides.

Figure 3 An approach to the design of a nonpeptide, delta-selective opioid antagonist based on the message-address concept. The message and address components of the delta-selective peptide enkephalin (upper) are compared to those in an opiate (lower).

The rationale for the design of naltrindole (NTI, 82) by Portoghese and his collaborators [170] was based on the message-address concept [171, 172], This design strategy for nonpeptide 8 selective antagonists employed the naltrexone pharmacophore for the message moiety and a key element in the leu-... 

Fig. 13 Message-Address Concept proposed for opioid antagonists. Reprinted from [28] with permission from Elsevier. Copyright (2008)...

Dondio G, Ronzoni S, Eggleson DS et al (1997) Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept. J Med Chem 40 3192-3198... 

Portoghese, P. S. Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists. Trends Pharmacol. Sci. 1989,10, 230-235. 

Metzger, T. G., Paterlini, M. G., Portoghese, P. S., Ferguson, D. M. (1996). Application of the message-address concept to the docking of naltrexone and selective naltrexone-derived opioid antagonists into opioid receptor models. Neurochemical Research, 21, 1287-1294. 

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