Mesoporphyrin iron complexes

Manganese(VI) complexes, 109-111 Manganese(VII) complexes, 109-111 Marcasite, 1240 Mercury compounds ruthenium complexes, 280 Mesoperrhenates, 198 Mesoporphyrin iron complexes, 1266 Methemerythrin, 254 Molybdenum-iron-sulfur complexes, 241 MOssbauer spectroscopy iron, 1181... 

Clezy s modification of the MacDonald synthesis using a 5,5 -diformyl-pyrro-ketone instead of a diformyl-pyrromethane has been extended to the synthesis of the a-oxy-derivative of mesoporphyrin IX and to the y-oxy-derivative of protoporphyrin IX (Scheme 3). The iron complex of the latter undergoes oxidative ring opening in pyridine solution to form biliverdin IX-y (25), the parent compound of a series of three green pigments found in certain types of butterflies and caterpillars this provides a model for their probable mode of biosynthesis. 

Peptide Ac-AKEAAHAEAAEAA-NH2 was synthesized using Boc chemistry on MBHA resin (100-200 mesh, 1% DVB, substitution level 0.53 mmol-g 1). Purification was carried out by HPLC on a 2.2-cm Vydac C18 column using a gradient of MeCN/H,0 in 0.1% TFA (5 to 40% over 40 min) at a flow rate of SmL-min Mesoporphyrin IX was converted into the iron(III) complex by refluxing with excess Fe(OAc)2 in AcOH.11"1 The bis(4-nitrophenyl) ester of iron(III) mesoporphyrin IX was subsequently prepared using the method of Collman et al.12001... 

Kurland et al. (64) observed hyperfine-shifted resonances of ferrimyoglobin between —20 and —90 ppm. Comparison with the spectra of the iron(III)-complexes with protoporphyrin IX, deuteroporphyrin IX, and mesoporphyrin IX seems to indicate that four of the low field resonances correspond to the four ring methyl groups. Additional lines at high fields from DSS were observed in ferrimyoglobin (116), and in high spin porphyrin-iron(III) complexes (Caughey et al. (19)). The observation... 

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