Mesodermal differentiation

Source of MSC Frequency of CFU-F at the isolation Proliferation capacity Senescence Mesodermic differentiation capacity Differentiation towards other lineages Ref. 

Analysis by RT-PCR of expression of a panel of hematopoietic markers indicated that visceral endoderm signaling results in activation not only of genes characteristic of differentiated erythroid cells globin) but also of early hematopoietic genes such as GATA-1 and CD-34. The presence of VE in recombinants did not result in promiscuous activation of mesoderm differentiation markers cardiac myosin, which is expected to be expressed only in cardiac tissue (and therefore only at a later developmental stage), was not detected in anterior or posterior epiblast pieces or in recombinants during the first 4 days in culture, but was detected in an older (10.5 dpc) embryonic control. 

Burdsal, C. A., Damsky, C. H., and Pedersen, R. A. 1993. The role of e-cadherin and integrins in mesoderm differentiation and migration at the mammahan primitive streak. Development 118(3) 829-44. 

Engineering the Pluripotent Stem Cell Niche for Directed Mesoderm Differentiation... 

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