Mesitylene-2-sulfonyl -3-nitro-l,2,4-triazole MSNT

Solubility insoluble in H2O soluble in CH2CI2, CHCI3, DMF, and pyridine. 

Form Supplied in crystalline solid commercially available. 

Analysis of Reagent Purity the reagent may be checked by mp or analyzed by NMR. 

Preparative Methods this reagent can be prepared by the reaction of 3-nitro-1,2,4-triazole (1 equiv) and mesitylsulfonyl chloride (1 equiv) in the presence of triethylamine (1 equiv) in dioxane at 0 °C for 1 h. The product is isolated in 92% yield after crystallization from benzene.  

Handling, Storage, and Precautions this reagent may be an irritant. Avoid contact with the skin. It should be handled under nitrogen and stored below — 20 °C. 

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Synthesis of 01igodeo iQrribonucleotides by the Phosphotriester Method. l-(Mesitylene-2-sulfonyl)-3-nitro-l,2,4-triazole-(MSNT) has been widely used as a condensing agent for the synthesis of oligodeoxynucleotides by the phosphotriester method. ... 

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