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Menaquinones biosynthesis

Fig. 6.20 Aurachin RE a tuberculosis (TB) drug, and oxidative modification of menaquinone by M tuberculosis CYP128A1. a Aurachin RE an alkaloid antibiotic with anti-TB activity through its inhibition of menaquinone biosynthesis (enzyme MenA) [339], R. erythropolis RauA (CYP1050A1) catalyzes the N-hydroxylation of an aurachin intermediate to produee the aetive auraehin RE compound [337], b Dihydromenaquinone MK9, the major quinol electron carrier in Mtb respiration, is likely... Fig. 6.20 Aurachin RE a tuberculosis (TB) drug, and oxidative modification of menaquinone by M tuberculosis CYP128A1. a Aurachin RE an alkaloid antibiotic with anti-TB activity through its inhibition of menaquinone biosynthesis (enzyme MenA) [339], R. erythropolis RauA (CYP1050A1) catalyzes the N-hydroxylation of an aurachin intermediate to produee the aetive auraehin RE compound [337], b Dihydromenaquinone MK9, the major quinol electron carrier in Mtb respiration, is likely...
Debnath J, Siricilla S, Wan B, Crick DC, Lenaerts AJ, Franzbiau SG, Kurosu M (2012) Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis. J Med Chem 55 3739-3755... [Pg.389]

Dansette, P. and Azerad, R. (1970) New intermediate in naphthoquinone and menaquinone biosynthesis. Biochem. Biophysic. Res. Comm. 40, 1090-1095... [Pg.381]

Baldwin, Snyder and Rapoport in an important paper have directed attention at the symmetry (or otherwise) of the as yet unidentified naphthalenic intermediate in bacterial menaquinone biosynthesis. 7-[ C]-Shikimic acid, prepared by the procedure of Grewe and Vangermain from 3,4,5-triacetoxycyclohexanone, was incorporated (0.25 per cent) into 9-dihydromenaquinone (1) in Mycobacterium phlei. Degradation gave C-1 and C-4 of the original... [Pg.302]

Weische, a., and E. Leistner Cell Free Synthesis of o-Succinylbenzoic Acid from Iso-chorismic acid, the Key Reaction in Vitamin K2 (menaquinone) Biosynthesis. Tetrahedron Lett. 26 (12), 1487 (1985). [Pg.150]

Kolkmann, R., and E. Leistner Synthesis and Revised Structure of the o-Succinyl benzoic Acid Coenzyme A Ester, an Intermediate in Menaquinone Biosynthesis. Tetrahedron Lett. 26 (14), 1703 (1985)... [Pg.150]

Guest, J.R., Menaquinone biosynthesis mutants of Escherichia coli vitamin Kj requiring 2-succi-nylbenzoate,/. Bacteriol, 130,1038, 1977. [Pg.2391]

See other pages where Menaquinones biosynthesis is mentioned: [Pg.266]    [Pg.95]    [Pg.133]    [Pg.95]    [Pg.133]    [Pg.1308]    [Pg.411]    [Pg.414]    [Pg.274]    [Pg.95]    [Pg.133]    [Pg.308]    [Pg.54]    [Pg.258]    [Pg.259]    [Pg.259]    [Pg.425]    [Pg.323]    [Pg.94]    [Pg.1807]    [Pg.2391]   
See also in sourсe #XX -- [ Pg.91 , Pg.92 , Pg.93 , Pg.302 , Pg.303 ]



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