Memory, epigenetic

Bird, A. (2002) DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21. 

Rakyan VK, Preis J, Morgan HD, Whitelaw E. The marks, mechanisms and memory of epigenetic states in mammals. Biochem J 2001 356 1-10. 

The second model illustrates the point that more than one kind of memory can be responsible for the reconstruction from incomplete information that takes place during the (epigenetic) formation of an organism. Barbieri proposes that two kinds of memory are in fact responsible for the development of multicellular animals - one for the earlier stages, the other for the later ones. He shows how the existence of these two kinds of memory might account for the pattern of macroevolution, notably the Cambrian explosion. 

Epigenetics has been included in several toxicological hypotheses. According to the Barker hypothesis a toxic event in early life can be the reason for the development of late-onset disease [125], As epigenetic mechanisms can act as molecular memories of previous stress, they are very likely to contribute to such disease mechanisms. Thus, it is important to understand by which mechanisms chemicals and drugs may interfere with epigenetic mechanisms. 

As an epigenetic mechanism of transcriptional control, chromatin modification has been shown to participate in maintaining cellular memory and may underlie the strengthening and maintenance of synaptic connections required for long-term... 

Prins, G. S. Estrogen Imprinting When Your Epigenetic Memories Come Back to HsaniYov. Endocrinology 149 (2008) 5919-21. 

Sailaja, B.S., Cohen-Carmon, D., Zimmerman, G., et al, 2012. Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4. Proc. Natl. Acad. Sci. USA 109 (52), E3687-E3695. 

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