Memory CREB, role

The role of CREB in learning and memory was first anticipated by screening Drosophila mutants in a learning and memory task in which flies were behaviorally tested... 

Most importantly, later genetic experiments, using conditional knockout technique to delete all forms of CREB in either the entire forebrain or hippocampus, showed that these conditional knockout mice have normal hippocampal early- and late-phase LTP, and normal performance in hippocampal-dependent memory tasks [13]. Therefore, those newer findings cast significant doubt on the role of CREB as a central switch for long-term plasticity. 

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