Membranes and Molecules Oriented Therein

It has been shown that the secondary structure and topology of membrane proteins can be described by inspection of two-dimensional dipolar 

The use of three-dimensional spectroscopy involving chemical shift/ H- N dipolar coupling/ N chemical shift correlation has been shown to improve spectral resolution in studies of membrane proteins with helices aligned parallel to the membrane surface. Such a measurement on the antibiotic peptide magainin enabled the three-dimensional orientation of this helical peptide to be determined in the lipid bilayer. The orientation of the insect antiobiotic peptide cecropin A in the phospholipid bilayer membrane has been determined using solid-state NMR spectroscopy and the result discussed in relation to the mechanism of action of the peptide.  

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Reviews, Theory and General Studies New Techniques Studies of Oriented Small Molecules Relaxation and Dynamic NMR Studies Novel Mesophases and Orientational Order Membranes and Molecules Oriented therein Weak Ordering and Biomolecular Studies. 

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