Membrane proteins novel methods

Schneider, G., Neidhart, W., and Adam, G. Integrating virtual screening methods to the quest for novel membrane protein ligands. Curr. Med. Chem. CNS Agents 2001, 3, 99-112. 

Tennikova, T. B., Svec, F., and Belenkii, B. G. (1990). High-performance membrane chromatography. A novel method of protein separation. J. Liquid Chromatogr. Related Technol. 13 63-70. 

Nelson, N. (1987) A novel method for the detection of receptors and membrane proteins by scintillation proximity radioassay. Anal. Biochem. 165, 287-293. 

Although the structure of a protein may encourage the use of one type of immobilization chemistry in preference to others, the optimal strategy must be empirically determined. Efficient coupUng, while important, must not be at the expense of activity. In this section, some immobilization chemistry options for potentially problematic interactants such as acidic proteins, are discussed. Secondly, novel ways to immobiUze membrane proteins are presented and finally, some recently developed methods of thiol couphng are addressed. 

T. B. Tennikova, M. Bleha, F. Svec, T. V. Almazova and B. G. Belenkii, High-Performance Membrane Chromatograpy of Proteins. A Novel Method of Protein Separation, J. Chromatogr., 555 (1991) 97. 

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