15- Membered macrolides mycinamicin

A few neutral 16-membered macrolides have been isolated. The structure of chalcomycin, produced by S. bikiniensis. was established as a 16-membered lactone having two neutral sugars, D-chalcose and D-mycinose. Its aglycone resembles that of the mycinamicins, but differs by a hydroxyl group, the stereochemistry of which is uncertain, at C-8 and a methyl group at C-15. 

Mycinamicins. A set of new basic sixteen-membered macrolide antibiotics have been isolated from Micromonospora spp. and called mycinamicins I-V mycinamicins I, II, IV, and V have been assigned the structures (98a and h) and (99a and b), respectively", and mycinamicin III has been shown to be... 

Minor components of the mycinamicin complex obtained from Micromonospora griseorubida have been isolated and characterized they contain mycinose and/or desosamine separately attached to the 16-membered macrolide ring. Some derivatives of angolamycin together with the parent compound have been identified in a broth of a Streptomyces strain (86-070) the same... 

The biosynthesis of mycinamicins (16-membered macrolides carrying desosamine and mycinose) by a blocked mutant of Micromonospora griseorubida has been studied. 

On the other hand, although PMS-resistant S. aureus was first described as an inducible MS-like resistant strain [127], it was later found that the strain conferred inducible resistance to mycinamicin, a 16-membered-ring macrolide, in addition to 14-membered-ring macrolides and streptogramin type B antibiotics. Matsuoka et al. disclosed that the gene product of S. auerus msrSA including msrSA, MsrSA protein, is 98% similar to the S. epidermidis MsrA protein [45, 59, 122, 128, 197]. 

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