Memantine safety

Lactation It is not known whether memantine is excreted in human breast milk. Children There are no adequate and well-controlled trials documenting the safety and efficacy of memantine in any illness occurring in children. 

Orgogozo J-M, Rigaud A-S, Stoffler A, et al Efficacy and safety of memantine in patients with mild to moderate vascular dementia a randomized, placebo-controlled trial (MMM300). Stroke 3 1834-1839, 2002... 

Hare, W. A., WoldeMussie, E., Weinreb, R. N., Ton, H., Ruiz, G., Wijono, M., Feldmann, B., Zangwill, L., and Wheeler, L. (2004). Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, II Structural measures. Invest. Ophthalmol Vis. Sci. 45, 2640-2651. 

Bullock R. Efficacy and safety of memantine in moderate-to-severe Alzheimer disease the evidence to date. Alzheimer Dis Assoc Disord 2006 20(l) 23-9. 

Yang Z, Zhou X, Zhang Q (2013) Effectiveness and safety of memantine treatment for Alzheimer s disease. J Alzheimers Dis 36 445-458... 

An in vitro study in rats suggested that memantine does not attenuate the anticholinesterase effects of donepezil at therapeutic concentrations. In a later study 19 healthy subjects were given memantine 10 mg before and on the last day of taking donepezil (5 mg daily for 7 days then 10 mg daily for 22 days). The pharmacokinetics of both drugs were not significantly affected by concurrent use, and the effects of donepezil on anticholinesterase were also unaffected. Furthermore, an efficacy and safety study of one year s duration has reported that the combination is well tolerated and beneficial. ... 

Fig. 2 EEG spectral changes as a seizure safety biomarker. Heat map shows spectral changes from EEG recordings in mice (n = 5) dosed with memantine 25 mg/kg i.p. Baseline recordings lasting 30 min are delineated by white dotted line. Frequency changes are calculated with a fast Fourier transform. Memantine causes a significant increase in gamma (>30 Hz) and beta (13-30 Hz) frequency density at sub-seizure threshold doses (<25 mg/kg i.p.), as shown by dark red coloration on the heat map. Data are unpublished...

Thomas SJ, Grossberg GT. Memantine a review of studies into its safety and efficacy in treating Alzheimer s disease and other dementias, din Interv Aging 2009 4 367-77. 

Doody RS, Geldmacher DS, Farlow MR, Stm Y, Moline M, MackeU J. Efficacy and safety of donepezil 23 mg versus donepezil 10 mg for moderate-to-severe Alzheimer s disease a subgroup analysis in patients already taking or not taking concomitant memantine. Dement Geri-atr Cogn Disord 2012 33(2-3) 164-73. 

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