Meliacins

N.A. Meliacins, triterpenoid bitters, tannins, flavonoids.100 For hemorrhoids, malaria, peptic ulcers, intestinal worms. Antifungal, antiviral, antiinflammatory, antibacterial. 

Azadirachtin, meliacin, azadironic acid bitter limonoids (Nortriterpenoids). Nimbibin, nimbin, salanin. Sesquiterpenes. Limonoids,... 

The potent tetranortriterpenoki limonoids of A. indica (neem) and M. azedarach (chinaberry) (i.e., meliacins) are considered to be among the most promising and interesting of the plant-derived insecticidal compounds yet discovered (17). Azadirachtin (Figure 2) is considered to be the prototype compound for this class of feeding deterrent (antifeedant) and insecticidal substances (17.18.28-31 k... 

Melanocidin A, M-126 Melanocidin B, M-127 Melastin, M-128 Melezitose, M-129 Meliacin, M-130 Melibiitol, M-131 Melibionic acid, M-132 Melibiosamine, A-203 Melibiose, G-145 Melibiulose, P-77 Melitose, R-1 Melitriose, R-1 Melizitose, M-129... 

Several compounds have been isolated from different parts of the plant. Azadirachtin, found in the seed, is believed to be one of the active ingredients. Nim-bidin, nimbin, sodium nimbidinate and nimbidol are other compounds isolated from the oil. The leaves yield meliacin, nimbolide, quercetin and P-sitosterol. The bark contains several bitter principles, peptidoglycans, nimbin, nimbidic acid, nim-biol and deacetylnimbin [62, 63]. 

A simple meliacin (7Gracetoxymeliaca-14,20,22-trien-3-one) has been converted into azadirone, a naturally occurring compound.Resibufogenin has been transformed into a member of the pregnane series. 

Triterpenoids and Their Derivatives. Triterpenoids and their derivatives represent the most characteristic types of compounds present in A, indica (Figure 2.) These compounds can be divided into two major classes, triterpenoids (protomeliacins) and meliacins (limonoids or tetranortriterpenoids). 

Meliacins. Meliacins (limonoids) are derivatives of triterpenes in which four side chain carbon atoms have been lost and the remaining carbon atoms have been... 

Arndt, R. R., and W. H. Baarschers The Structure of Phragmalin, a Meliacin with a Norbornane Part Skeleton. Tetrahedron 28, 2333 (1972). 

The Synthesis of the Simplest Meliacins (Limonoids) from Tetranortirucallane... 

The Conversion of Turreanthin and Turreanthin A into Simple Meliacins by a... 

Ekong, D. E. U. Chemistry of the Meliacins (Limonoids). The Structure of Nimbolide, a New Meliacin from Azadirachta indica. J. Chem. Soc. Chem. Commun. 1967, 808. 

Ekong, D. E. U., and E. O. Olagbemi Novel Meliacins (Limonoids) from the Wood of Pseudocedrela kotschyii. Tetrahedron Letters 1967, 3525. 

Halsall, T. G., and J. A. Troke The Structure of Three New Meliacins Isolated from Khaya anthotheca heartwood. J. Chem. Soc. Perkin Trans. I, 1975, 1758. 

Buchanan, J. G. St. C., and T. G. Halsall The Conversion of Turraeanthin and Turraeanthin A into Simple Meliacins by a Route Involving an Oxidative Rearrangement of Probable Biogenetic Importance. J. Chem. Soc. (C) 1970, 2280. 

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