Melanoma diagnosis

Rossen, K., Thomsen, H.K., Gniadecki, R., Hansen, LK. andWulf H.C. (2004) Melanoma diagnosis by Raman spectroscopy and neural networks structure alteration in proteins and lipids in intact cancer tissue. J. Invest. Dermatol, 122, 443-9. 

King R, Weilbaecher KN, McGill G, et al. Microphthalmia transcription factor a sensitive and specific melanocyte marker for melanoma diagnosis. Am J Pathol. 1999 155 731-738. 

What should be done to confirm the diagnosis of malignant melanoma ... 

A new series of amide derivatives 293-300 for diagnosis and therapy of disseminated malignant melanoma has been labelled437 139 with iodine-125 exchange between iodoaryl amides and Na125I. These have been used for injection in whole-body autoradiography... 

The rationale for the court s opinion was that the diagnosis of cataract (a disease ) required dilation of the pupil and that had dilation been performed at the time of the optometrist s examination, the possibility of a retinal detachment could have been ruled out. In finding the optometrist liable, the court imposed a medical standard of care.Therefore a dilated fundus examination should be used whenever best-corrected visual acuity is reduced, and coexisting disease should be considered a possibihty until an examination determines otherwise. Optometrists may be held responsible for the diagnosis of intraocular tumors—even those as rare as malignant melanoma—in symptomatic patients. 

Bieiberg, H., La Meir, E., Lejenne, F. Laparoscopy in the diagnosis of hver metastases in 80 cases of malignant melanoma. Endoscopy 1980 12 215-218... 

Faraj BA, Camp VM, Murray DR, Rutner M, Hearn J, Nixon D. Plasma L-dopa in the diagnosis of malignant melanoma. Clin Chem 1986 32 159-61. 

Figure 4.4 Example of longitudinal follow-up by plasma L-DOPA/L-tyrosine ratio. A 52-year-old male (initial melanoma right arm) was monitored by the L-DOPA/L-tyrosine ratio, SIOOB and melanoma inhibitory activity (MIA) for 21 months. Six major clinical events are reported 1, second local recurrence, 3 years after initial diagnosis 2, bone and pulmonary metastases (stage IV) 3, evolution of subcutaneous metastases 4, evolution of cutaneous and pulmonary metastases 5, metastases to axillary nodes 6, death...

A number of different tumor antigens have been identified on melanoma cells by the use of monoclonal antibodies in both human and murine models. Melanoma-associated antigens (MAAs) have been identified in the cellular membrane and cytoplasm of melanoma cells. GangUoside antigens have been of particular interest in the development of immunotherapy for melanoma. A large number of monoclonal antibodies to MAAs have been developed and are currently being used in clinical trials for the diagnosis and the therapy of melanoma. 

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