Megathura crenulata

Senozan, N. et al. (1981) Hemocyanin of the giant keyhold limpet, Megathura crenulata. In Invertebrate Oxygen Binding Proteins Structure, Active Sites, andFunction (J. Lamy, and J. Lamy, eds.), pp. 703-717. Dekker, New York. 

Keyhole limpet hemocyanin (KLH) is an immune stimulant and a hapten carrier, derived from a circulating glycoprotein of the marine mollusk Megathura crenulata. KLH has significant antiproliferative effects in vitro against several types of cancers (23). It has also been conjugated to a variety of immunogens and used as a vaccine adjuvant (24). 

Senozan, N. el al. (1981) Hemocyanin of the giant keyhold limpet, Megathura crenulata. in... 

Examples of the application of TEM to the study of respiratory proteins are shown in Figures 1 and 2. The first example (Figure lA) of negatively stained key-hold limpet Megathura crenulata) hemocyanin (KLH) shows a 2D crystal of the side-on image... 

Key hole limpet hemocyanin Phase III Megathura crenulata Anticancer Protein... 

Kurokawa, T., Wuhrer, M., Lochnit, G., Geyer, H., Markl, J., and Geyer, R. (2002) Hemocyanin from the keyhole limpet Megathura crenulata (KLH) carries a novel type of N-glycans with Gal(pi-6)Man-motifs. Eur.J. Biochem., 269, 5459-5473. 

Oakes, F.R., McTee, S., McMullen, J., Culver, C.S., and Morse, D.E. (2004) The effect of captivity and diet on KLH ratios in Megathura crenulata. Comp. Biochem. Physiol., 138A, 169-173. 

Senozan, N.M. and Briggs, M. (1989) Hemocyanin levels in the giant keyhole hmpet, Megathura crenulata, from the coast of cahfomia. Comp. Biochem. l%ysiol., 94A, 195-199. 

Gebauer, W., Harris, J.R., and Markl, J. (2002) Topology of the 10 subunits within the decamer of KLH, the hemocyanin of the marine gastropod Megathura crenulata. J. Struct. Surg., 139, 153-159. 

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