Phenothiazines Mefloquine

PROPAFENONE I. ANTIARRHYTHMICS - disopyra-mide, procainamide 2. ANTIBIOTICS - macrolides (especially azithromycin, clarithromycin, parenteral erythromycin, telithromycin), quinolones (especially moxifloxacin), quinupristin/ dalfopristin 3. ANTICANCER AND IMMUNOMODULATING DRUGS -arsenic trioxide 4. ANTIDEPRESSANTS - TCAs, venlafaxine 5. ANTIEMETICS-dolasetron 6. ANTIFUNGALS-fluconazole, posaconazole, voriconazole 7. ANTIHISTAMINES - terfenadine, hydroxyzine, mizolastine 8. ANTI-M ALARIALS - artemether with lumefantrine, chloroquine, hydroxychloroquine, mefloquine, quinine 9. ANTIPROTOZOALS - pentamidine isetionate 10. ANTIPSYCHOTICS-atypicals, phenothiazines, pimozide II. BETA-BLOCKERS - sotalol 12. BRONCHODILATORS -parenteral bronchodilators 13. CNS STIMULANTS - atomoxetine Risk of ventricular arrhythmias, particularly torsades de pointes Additive effect these drugs prolong the Q-T interval. Also, amitriptyline, clomipramine and desipramine levels may be t by propafenone. Amitriptyline and clomipramine may t propafenone levels. Propafenone and these TCAs inhibit CYP2D6-mediated metabolism of each other Avoid co-administration... 

ANTIMALARIALS - artemether with lume-fantrine, chloroquine, hydroxychloroquine, mefloquine, quinine 9. ANTIPROTOZOALS -pentamidine isetionate 10. ANTI-PSYCHOTICS - atypicals, phenothiazines, pimozide 11. BETA-BLOCKERS - sotalol 12. BRONCHODILATORS-parenteral bronchodilators 13. CNS STIMULANTS -atomoxetine... 

ANTIDEPRESSANTS - TCAs, ven-lafaxine 5. ANTIEUNGALS-fluconazole, posaconazole, voriconazole 6. ANTIHISTAMINES-terfenadine, hydroxyzine, mizolastine 7. ANTI-MALARIALS - artemether with lumefantrine, chloroquine, hydroxychloroquine, mefloquine, quinine 8. ANTIPROTOZOALS - pentamidine isetionate 9. ANTIPSYCHOTICS -atypicals, phenothiazines, pimozide... 

ANTiHiSTAMiNES -terfenadine, hydroxyzine, mizoiastine 8. ANTi-MALARiALS - artemether with iumefantrine, chioroquine, hydroxy-chioroquine, mefloquine, quinine 9. ANTiPROTOZOALS - pentamidine isetionate 10. ANTiPSYCHOTiCS-atypicais, phenothiazines, pimozide... 

An isolated report describes cardiopulmonary arrest in a patient taking mefloquine with propranolol. The WHO have issued a warning about the concurrent use of mefloquine with an-tiarrhythmics, beta blockers, calcium-channel blockers, antihistamines, phenothiazines, and some related antimalarials. For mention that halofantrine should not be used with or after mefloquine, because of a clinically significant lengthening of the QT interval, see Halofantrine + Miscellaneous , p.229. 

---