Mefloquine Ethanol

FIGU RE 1.38 Chromatograms of LPME-treated drug-free plasma, mirtazapine enantiomers, and mefloquine.156 Chromatograms refer to drug-free plasma (A) plasma spiked with 62.5 ng mL-1 of (+)-(5)-mirtazapine (2) and (-)-(i )-mirtazapine (3) and 500 ng rnL-1 of (R, S)-mefloquine (1,4) (B) plasma sample from a patient treated with 15 mg/day of rac-mirtazapine (C). All samples were pre-treated by LPME. The analysis was performed on a Chiralpak AD column using hexane ethanol (98 2, v/v) plus 0.1% diethylamine at a flow rate of 1.5 mL min-1, A = 292 nm. (+)-(5)-mirtazapine (2), (-)-(f )-mirtazapine (3) and (1, 4) internal standard. (Reproduced with permission from Elsevier.)... 

Wittes RC, Saginur R. Adverse reaction to mefloquine associated with ethanol ingestion. CMAJ 1995 152(4) 515-17. 

Mefloquine hydrochloride is an interesting case of a compound that forms stoichiometric 1 1 solvates on cooling hot (50°C) saturated acetone solutions (Form B, acetone solvate 1 1), hot (50°C) saturated isopropanol (Form I, isopropanol solvate 1 1), and a nonstoichiometric ethanol solvate (2.12% ethanol) from hot (50°C) saturated ethanol. Form E, whose x-ray powder pattern does not change following heating to 80°C, in spite of a decrease in the ethanol level to 0.12%. Mefloquine hydrochloride can also be obtained in a nonsolvated form from hot (70°C) saturated acetonitrile (Form A) and as two hemihydrates from water (Forms D and C) prepared at room temperature and at30°C [82]. 

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