Medroxyprogesterone long-term effects

Further reports on the antifertility long term effectiveness of injectable medroxyprogesterone acetate (3) (150 mg) in postpartum women and of dihydroxyprogesterone acetophenonide (4) with estradiol enanthate (150 mg + 10 mg), have been published. 

Progestin-only contraceptives (Fig. 4) contain low-doses of progestins (e.g. 350 pg norethindrone or 75 pg norgestrel) that have to be administered daily without interruption. The lowest expected failure rate during the first year of use is 0.5%, while the typical failure rate amounts to 3%. Subdermal implants of norgestrel (216 mg) for sustained release provides for long-term (for up to 5 years) contraceptive effects characterized by failure rates of only 0.05%. Reliable contraception for 3 months can be achieved by an intramuscular injection of a crystalline suspension of 150 mg medroxyprogesterone acetate (Fig. 3) (failure rate 0.3%). 

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