Medroxyprogesterone acetate depot injections

La Vecchia C. Depot-medroxyprogesterone acetate, other injectable contraceptives, and cervical neoplasia. Contraception 1994 49(3) 223-30. 

The adverse effects of norethisterone enantate when used as a 2-monthly injectable contraceptive have been compared in various populations with those of depot medroxyprogesterone acetate and were found to be closely similar (5,6). 

Kaunitz AM. Long-acting injectable contraception with depot medroxyprogesterone acetate. Am J Obstet Gynecol 1994 170(5 Pt 2) 1543-9. 

Joshi UM, Virkar KD, Amatayakul K, Singkamani R, Bamji MS, Prema K, Whitehead TP, Belsey MA, Hall P, Parker RA. Metabolic side-effects of injectable depot-medroxyprogesterone acetate, 150 mg three-monthly, in undernourished lactating women. WHO Task Force on... 

Effective contraception can also be achieved by injecting 150 mg of depot medroxyprogesterone acetate (DMPA) every 3 months. After a 150 mg dose, ovulation is inhibited for at least 14 weeks. Almost all users experience episodes of unpredictable spotting and bleeding, particularly during the first year of use. Spotting and bleeding decrease with time, and amenorrhea is common. This... 

Progestin preparations. Depot formulations for Lm. injection are 17-a-hydroxy-progesterone caproate and medroxyprogesterone acetate. Preparations for oral use... 

Kaunitz AM. Injectable depot medroxyprogesterone acetate contraception An update for US clinicians. Int J Fertil Women s Med 1998 43 73-83. 

Intractable dysmenorrhea or uterine bleeding Conjugated estrogens, ethinyl estradiol, oral contraceptive, GnRH agonist, depot injection of medroxyprogesterone acetate... 

Preliminary experiments on rats, using medroxyprogesterone acetate in microcrystalline suspension, seem to indicate that administration of depot o.c. s by jet injection through the skin may lead to more regular cycles without increased local pain during administration [1 ]. 

The use of a silastic vaginal ring impregnated with medroxyprogesterone acetate and inserted on day one of the cycle for 28 days represents yet another variation of the depot concept [167]. LH release and ovulation were inhibited as expected. Removal of the ring was followed by withdrawal bleeding in about 48 hours. In contrast to the depot injection, this technique provides rapid termination of drug action. 

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