Medium-sized-ring Oxygen-containing Heterocycles

8 Medium-sized-ring Oxygen-containing Heterocycles 

Many natural products and synthetic derivatives bearing a 2-benzoxepine unit are found to be a class of medicinally important compoimds, exhibiting 

Given the successful applications of radical cyclization in the construction of seven-membered-ring compounds from MBH adducts, Chattopadhyay and co-workers have designed and synthesized several novel MBH adducts that 

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A particularly useful general method for the synthesis of saturated nitrogen- and oxygen-containing partially unsaturated heterocycles, from 5-membered to medium ring-sized, is the Grubbs olefin metathesis applied, for example, to acyclic diaUcenyl-amines, as illustrated by syntheses of a dihydropyrrole and a tetrahydropyridine. ... 

The intramolecular cyclization of hydroxy ketones and thioketals, performed under mild conditions, is often used to produce oxygen-containing medium-ring size heterocycles. Upon treatment with silver perchlorate... 

Synthesis of Natural Products Containing Medium-size Oxygen Heterocycles by Ring-closing Alkene Metathesis... 

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