Medicines Cyclophosphamide

Figure 22.14. Metabolism of cyclophosphamide. The major therapeutic metabolite, phos-phoramide, is highlighted. [Adapted from Colvin, O. M. In Holland, J. F., Bast, R. C., Jr., Morton, D. L., Frei, E., Ill, Kufe, D. W., and Weichselbaum, R. R. (Eds.). Cancer Medicine, Vol. 1, 4th ed., Williams Wilkins, Baltimore, 1997, pp. 949-975.]...

Cyclophosphamide is used in human medicine as an antineoplastic (anticancer) agent in a variety of applications. Cyclophosphamide is a potent immunosuppressive agent and is used to prevent rejection episodes following renal, hepatic, and cardiac transplantation and in non-neoplastic disorders in which... 

Chu, D.T., W.L. Wong, and G.M. Mavligit. 1988b. Immimotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. /. Clin. Lab. Immunol. 25(3) 125-129. 

Kamanamool N, McEvoy M, Attia J, Ingsathit A, Ngamjanyaporn P, Thakkinstian A. Efficacy and adverse events of mycophenolate mofetil versus cyclophosphamide for induction therapy of lupus nephritis systematic review and meta-analysis. Medicine (Baltimore) 2010 89(4) 227-35. 

Knowing that mixtures such as cyclophosphamide and mesna [79] or cytotoxic and antiemetic medicines [80] are stable enough for a suitable period (for instance several days) to facilitate administration for nurses and patients. 

Aseptic handling of antineoplastic medicines, such as injections prepared with cyclophosphamide. 

Thatte UM, Chhabria S, Karandikar SM, Dahanukar SA (1987) Protective effects of Indian medicinal plants against cyclophosphamide neutropenia. J Postgrad Med 33 185-188... 

ViUa-Forte A, Clark TM, Gomes M, et al. Substitution of methotrexate for cyclophosphamide in Wegener granulomatosis a 12-year single-practice experience. Medicine (Baltimore) 2007 86(5) 269 277. 

---