Medical device-associated infections

In the final chapter, biofilm formation is reviewed, covering knowledge about structure and biosynthesis of polysaccharide intercellular adhesins (PIAs) which are central to biofilm formation. This comprehensive chapter explains all PIA-related principles of medical device-associated infections. 

Biomaterials and medical-device associated infections Edited by L Barnes and I. R. Cooper... 

Delaviz Y, Santerra JP, Cvitkovitch DG. In Cooper IR, Barnes L, editors. Biomaterials and medical device associated infections. Woodhead Publishing Cambridge, UK. 2015. p. 223-54. 

Bacterial infection associated with medical devices remains a challenge to modern medicine as they provide the surface and environment for bacterial colonisation. In particular, bacteria commonly adhere more preferably to hydrophobic materials, which are commonly used to make medical devices. Bacteria are also becoming increasingly resistant to common antibiotic treatments as a result of the misuse and abuse of antibiotics. There is an urgent need to find alternatives to antibiotics in the global prevention and treatment of device-associated infections. Silver NP have... 

Bisno A.L. Waidvogel F. A. (199A) Infections Associated with Indwelling Medical Devices, 2ndedn. 

S. aureus causes a variety of suppurative (pusforming) infections and toxinoses in humans. It may cause superficial skin lesions (boils and styes) infections such as pneumonia, mastitis, phlebitis, meningitis, and urinary tract infections and deep-seated infections such as osteomyelitis and endocarditis. S. aureus is associated with nosocomial infections of surgical wounds and infections with indwelling medical devices. S. aureus can cause toxic... 

DG Maki. Infections caused by intravascular devices used for infusion therapy pathogenesis, prevention and management. In AL Bisno, FA Waldvogel, eds. Infections Associated with Indwelling Medical Devices. Washington, DC ASM Press, 1994, pp. 155-212. 

This chapter will be focused on antimicrobial PUs for intravascular applications. First, a classification of the types of PU intravascular devices and their impact in the medical held will be inhoduced. Then, a survey of infections associated with intravascular devices in terms of incidence, etiology, and pathogenesis will be presented. Next, management of device-related infections and the role of modified PUs in preventing intravascular device-related infections will be discussed. Finally, the future direction of novel antimicrobial polymers as biomaterials for the development of devices preventing biofilm-based infections will be described. 

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