Medical applications mass transfer

Lindinger, W., Fall, R., Karl, T.G. (2001) Environmental, food and medical applications of proton-transfer-reaction mass spectrometry (PTR-MS). Adv. Gas Phase Ion Chem. 4 1-48. 

In some technological and medical applications protein adsorption and/or cell adhesion is advantageous, but in others it is detrimental. In bioreactors it is stimulated to obtain favourable production conditions. In contrast, biofilm formation may cause contamination problems in water purification systems, in food processing equipment and on kitchen tools. Similarly, bacterial adhesion on synthetic materials used for e.g. artificial organs and prostheses, catheters, blood bags, etc., may cause severe infections. Furthermore, biofilms on heat exchangers, filters, separation membranes, and also on ship hulls oppose heat and mass transfer and increase frictional resistance. These consequences clearly result in decreased production rates and increased costs. 

Zhan, X., Duan, J., Duan, Y. Recent developments of proton-transfer reaction mass spectrometry (PTR-MS) and its applications in medical research. Mass Spectrom. Rev. 32, 143-165 (2013)... 

ENVIRONMENTAL, EOOD AND MEDICAL APPLICATIONS OF PROTON-TRANSFER-REACTION MASS SPECTROMETRY (PTR-MS)... 

The development of proton-transfer-reaction mass spectrometry (PTR-MS) as a tool for the analysis of volatile organic compounds (VOCs) is described. PTR-MS is based on the rapid, non-dissociative transfer of protons from H30 to most common VOCs, but not to the principal gases in the air sample. Recent developments in the design of PTR-MS instruments allow detection of some VOCs in the parts per trillion by volume range. This sensitivity and the capability of PTR-MS instruments to be operated for extended periods in both laboratory and field settings has allowed exploration of many aspects of VOC analysis in environmental, food and medical applications. 

Lindinger, W. Hansel, A. Jordan, A. Online Monitoring of Volatile Oiganic Compounds at Pptv Levels by Means of Proton-Transfer-Reaction Mass Spectrometry (PTR-MS). Medical Applications, Food Control and Environmental Research. Int. J. Mass Spectrom. Ion Proc. 1998, J7J, 191-241. 

W Lindinger, A Hansel, A Jordan. On-line monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass spectrometry (PTR-MS) Medical applications, food control and environmental research. Int J Mass Spectrom Ion Processes 173 191-241, 1998. 

Lirk, R, Bodrogi, F., Rieder, J. (2004) Medical applications of proton transfer reaction-mass spectrometry ambient air monitoring and breath analysis. Int. J. Mass Spectrom. 239, 221. 

We have briefly mentioned the use of data on IMR in plasma modeling and for the understanding of interstellar molecular synthesis as well as of ionospheric chemistry, and we also want to point out the applications of IMR in various methods of chemical ionization. The most recent one, developed in our laboratory, namely proton-transfer reaction mass spectrometry (PTR-MS), allows for on-line monitoring of volatile organic compounds at levels as low as a few parts per trillion and is therefore applicable for environmental, food, and medical research involving investigations of fast metabolic and enzymatic processes. 

Thompson, X, Worthington, T. (2004) The proton transfer reaction mass spectrometer and its use in the medical sciences applications to drug assays and the monitoring of bacteria. International Journal of Mass Spectrometry, 239, 235-241. 

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