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Mediator secondary

Andersson T, Miners JO, Veronese ME, et al. Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism. Br J Clin Pharmacol 1994 37 597-604. [Pg.355]

Mediators secondary to free fatty acid release... [Pg.307]

Vainio, S., Karavanova, I., Jowett, A., Thesleff, I. 1993. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75, 45-58. [Pg.67]

Mutants of G. fujikuroi provide a useful means to investigate the biosynthesis of GAs and related diterpenes, the broad specificity of the enzymes mediating secondary metabolism, and the factors controlling the enzymes of individual biosynthetic steps. Their usefulness lies mainly in the ease of analysis of metabolic products from added substrates which normally are formed after the metabolic block. The main disadvantage lies in the acquisition of mutants and, although the halo-half seed bio-assay provides a rapid and sinq>le method of screening for presumptive mutants, the low frequency with which mutants are found with metabolic blocks along the pathway is a major draw-back. [Pg.33]

Related to peripheral release of Intracellular or humoral noxious mediators Secondary hyperalgesia... [Pg.20]

A-fiber nociceptors mediate secondary hyperalgesia to punctate stimuli through a second pathway. [Pg.20]

The pathway model makes a number of key predictions, including (a) a substantial role for hydrogen bond mediation of tunnelling, (b) a difference in mediation characteristics as a function of secondary and tertiary stmcture, (c) an intrinsically nonexponential decay of rate witlr distance, and (d) patlrway specific Trot and cold spots for electron transfer. These predictions have been tested extensively. The most systematic and critical tests are provided witlr mtlrenium-modified proteins, where a syntlretic ET active group cair be attached to the protein aird tire rate of ET via a specific medium stmcture cair be probed (figure C3.2.5). [Pg.2978]

As carbocations go CH3" is particularly unstable and its existence as an inter mediate m chemical reactions has never been demonstrated Primary carbocations although more stable than CH3" are still too unstable to be involved as intermediates m chemical reactions The threshold of stability is reached with secondary carbocations Many reactions including the reaction of secondary alcohols with hydrogen halides are believed to involve secondary carbocations The evidence m support of tertiary carbo cation intermediates is stronger yet... [Pg.160]

In another interesting application of this procedure, the acid-mediated cascade cyclization of (3-diketone diepoxide 73 involves the participation not only of the two oxirane rings and of the secondary alcoholic group, but also of one of the two carbonyl groups. In this way, besides the two adjacent C and D THF rings, the simultaneous construction of the spiroketal function between the B and C rings of etheromycin is obtained (compound 74, in a 70 30 mixture with 12 -epi compound Scheme 8.19) [37]. [Pg.284]

A problem with employment of ASON in a larger clinical setting is their poor uptake and inappropriate intracellular compartmentalization, e.g., sequestration in endosomal or lysosomal complexes. In addition, there is a need for a very careful selection of the ASON-mRNA pair sequences that would most efficiently hybridize. To date, several computer programs are used to predict the secondary and tertiary structures of the target mRNA and, in turn, which of the mRNA sequences are most accessible to the ASON. However, even with this sophisticated techniques, the choice of base-pairing partners still usually includes a component of empiricism. Despite these principal limitations, it has become clear that ASON can penetrate into cells and mediate their specific inhibitory effect of the protein synthesis in various circumstances. [Pg.186]

An alternative preparation of benzofurans was carried out via a microwave-assisted Mannich condensation of paraformaldehyde and a secondary amine followed by cyclization with an alkynyl phenol 185 mediated by alumina doped with Cul (Scheme 67). The reaction can be carried out in a single-step... [Pg.247]

N-Alkoxylamines 88 are a class of initiators in "living" radical polymerization (Scheme 14). A new methodology for their synthesis mediated by (TMSlsSiH has been developed. The method consists of the trapping of alkyl radicals generated in situ by stable nitroxide radicals. To accomplish this simple reaction sequence, an alkyl bromide or iodide 87 was treated with (TMSlsSiH in the presence of thermally generated f-BuO radicals. The reaction is not a radical chain process and stoichiometric quantities of the radical initiator are required. This method allows the generation of a variety of carbon-centered radicals such as primary, secondary, tertiary, benzylic, allylic, and a-carbonyl, which can be trapped with various nitroxides. [Pg.151]

The two major approaches to the use of medications in the secondary prevention or rehabilitation of alcohohsm are 1) direct efforts to reduce or stop drinking behavior by producing adverse effects when alcohol is consumed or by modifying the neurotransmitter systems that mediate alcohol reinforcement, and 2) the treatment of persistent psychiatric symptoms, with the aim of reducing the risk of relapse by reducing the motivation to use alcohol to self-medicate such symptoms. [Pg.19]

Moreover, a dramatic increase of the reaction rate was observed when the coupUng of aromatic imines mediated by samariiun diiodide was carried out in the presence of both water and a tertiary amine or tetramethylethylene-diamine (TMEDA) [29], causing the almost instantaneous formation of the 1,2-diamine, although with undetermined diastereoselectivity. Similarly, the samarium diiodide promoted reductive coupling of iminiiun ions formed in situ by reacting ahphatic aldehydes with secondary amines and benzotriazole occurred at temperatures as low as - 70 °C [30]. Even in this case a mixture of diastereomers with undetermined ratio was obtained nevertheless, the item of diastereoselectivity induced by a chiral amine (auxiliary) is worthy of investigation. [Pg.13]


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See also in sourсe #XX -- [ Pg.211 ]




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