Mechanistic subtypes

The premise of this book is based on the presumption that introductory organic chemistry entails very little memorization. As presented in the chapters contained herein, this presumption is valid provided the student adheres to the philosophy that the study of organic chemistry can be reduced to the study of interactions between organic acids and bases. At this point, use of the principles presented in this book, in conjunction with more detailed coursework, allows students a broader understanding of organic chemistry reactions as described using combinations of fundamental organic mechanistic subtypes. 

The mechanistic subtypes presented throughout this book include those related to the acid-base properties of organic molecules. These are protonations, deprotonations, and proton transfers. Mechanistic types based on solvation effects include solvolysis reactions, SN1, and El processes. Additional mechanisms utilizing ionic interactions include SN2, SN2, E2, 1,2-additions, 1,4-additions, and addition-elimination processes. Finally, those mechanistic types dependent upon the presence of cationic species include alkyl shifts and hydride shifts. 

Rohrer DK, Kobilka BK (1998) G protein-coupled receptors functional and mechanistic insights through altered gene expression. Physiol Rev 78 35-52 Rosin DL, Talley EM, Lee A, Stornetta RL, Gaylinn BD, Guyenet PG, Lynch KR (1996) Distribution of aj -adrenergic receptor like immunoreactivity in the rat central nervous system. J Comp Neurol 372 135-165 Ruffolo RR, Nichols AJ, Stadel ]M, Hieble JP (1993) Pharmacologic and therapeutic applications of a2-adrenoceptor subtypes. Aim Rev Pharmacol Toxicol 32 243-279... 

It may be noted that some medical databases refer to antithrombotic agents as ANTITHROMBINS. This is not an exact use of the term as antithrombins, mechanistically, are a subtype of anticoagulants. 

A subtype of the [l,3,2,3]-elimination is found in the quantitative [1,3,2,(1)3]-elimination of water from oxazepame (281) which produces the aldehyde 282 147). Here, both the 3-H and the 2/1-bond migrate. The deuteration experiment shows that there is no [l,3,(2)3,l]-elimination as depicted in 281. Nevertheless, there remain numerous, as yet hardly distinguishable mechanistic possibilities for the process 281 -> 282 147>. 

Synthetic, Structural, and Mechanistic Issues in the Development of a Subtype Selective GABA Partial Agonist Hypnotic Agent... 

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