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Mechanistic Models of Proton Translocation

6 MECHANISTIC MODELS OF PROTON TRANSLOCATION Loop Mechanisms [Pg.409]

In the chemiosmotic model, as first developed by Mitchell in the early 1960 s, proton translocation arises from transfer of electrons from an (H + + e ) carrier (such as FMNH2) to an electron carrier (such as an iron-sulfur protein), with expulsion of protons to the outer compartment of the inner mitochondrial membrane. This process is followed by electron transfer to an (H+ + e ) carrier, with uptake of protons from the matrix. In this model, the electron-transport chain is organized into three such loops, as shown in Fig. 14-5. [Pg.409]

S = oxidized substrate FeS = iron-sulfur protein a, o3, b. c, c = cytochromes  [Pg.409]

What experimentally testable predictions does the Mitchell loop mechanism make  [Pg.409]

This scheme makes two experimentally testable predictions  [Pg.409]


The chemiosmotic model requires that flow of electrons through the electron-transport chain leads to extrusion of protons from the mitochondrion, thus generating the proton electrochemical-potential gradient. Measurements of the number of H+ ions extruded per O atom reduced by complex IV of the electron-transport chain (the H+/0 ratio) are experimentally important because the ratio can be used to test the validity of mechanistic models of proton translocation (Sec. 14.6). [Pg.408]




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