Mechanisms related large artery

Stroke mechanisms related to large artery atherosclerosis... 

In the cuff pressure VS area model, the c parameter was still the source of error, especially for diastolic pressure. It caused pseudo-systolic hypotension and pseudo-diastohc hypertension. By comparing a large pulse to a small one, we noticed that the derivative went low in the high-pressure zone for the diseased artery and this did not happen for the normal artery therefore, we came up with a new rule that we call the oscillometry of false hypertension. At high blood pressure zone with the derivative less than 0.1, the artery is diseased and stiff, and it collapses easily. As mentioned earlier, the true measurement of the blood pressure should be independent of the arterial mechanics. However, in every modeling experiment, it was found that c was the source of error and its related plot was very different from the rest. Other parameters like a, b, and d did not change the accuracy of blood pressure measurement before and after normalization. Normalization did not even correct the inaccuracy caused by the c parameter. In the case of the diseased artery, the arterial stiffness did increase diastolic pressure by almost 8% (Table 12.2) and this was consistent with the theory of pseudo-hypertension. 

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