Mechanism Trichoderma reesei

Table I. Biochemical Mechanisms Controlling Cellulase Synthesis and Activity in Trichoderma reesei...

El-Gogary, S., Leite, A., Crivellaro, O., Eveleigh, D., and El-Dorry, H. 1989. Mechanism by which cellulose triggers cellobiohydrolase I gene expresion in Trichoderma reesei. Proc. Natl. Acad. Sci.,86, 6138-6141. 

Gong C-S, Ladisch MR, Tsao GT (1977) Cellobiase from Trichoderma viride-. purification, properties,kinetics, and mechanism. Biotechnology and Bioengineering 19 959-981 Gong C-S, Ladisch MR, Tsao GT (1979) Biosynthesis, purification and mode of action of cellulase of Trichoderma reesei-. hydrolysis of cellulose mechanisms of enzymatic and acid catalysis. Advances in Chemistry Series vol. 181, American Chemical Society, Washington, DC, pp 261-287... 

Ladisch MR, Gong C-S, Tsao GT (1980) Cellobiose hydrolysis by endoglucanase (glucan glucanohydrolase) from Trichoderma reesei-. kinetics and mechanism. Biotechnology and Bioengineering 22 1107-1126... 

The principal features of a mathematical model described for the enzymatic hydrolysis and fermentation of cellulose by Trichoderma reesei are the assumption of two forms of cellulose (crystalline and amorphous), two sugars (cellobiose and D-glucose), and two enzymes (cellulase and j3-D-glucosidase). An inducer-repressor-messenger RNA mechanism is used to predict enzyme formation, and pH effects are included. The model consists of 12 ordinary differential equations for 12 state variables and contains 38 parameters. The parameters were estimated from four sets of experimental data by optimization. The results appear satisfactory, and the computer programs permit simulation of a variety of system changes. 

Ahamed A, Vermette P. (2010). Effect of mechanical agitation on the production of cellulases by Trichoderma reesei RUT-C30 in a draft-tube airlift bioreactor. Biochem Eng J, 49, 379-387. 

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