Mechanism Boyer

Boyer, P. D., 1970. The Enzymes, 3rd ed. New York Academic Pre.s.s. A good reference. source for the mechanisms of action of vitamins and coenzymes. 

Hart, R. C., Stempel, K. E., Boyer, P. D., and Cormier, M. J. (1978). Mechanism of the enzyme-catalyzed bioluminescent oxidation of coelenterate-type luciferin. Biochem. Biophys. Res. Commun. 81 980-986. 

Hsiou Y, Ding J, Das K, Clark AD Jr, Boyer PL, Lewi P, Janssen PA, Kleim JP, Rosner M, Hughes SH, Arnold E (2001) The Lysl03Asn mutation of HIV-1 RT a novel mechanism of drug resistance, J Mol Biol 309 437 45... 

Bohan, A., Boyer, J. L., Mechanism of hepatic transport of drugs implications for cholestatic drug reactions, Semin. Liv. Dis. 2002, 22, 123-136. 

Boyer, I.J. and V. Di Stefano. 1985. An investigation of the mechanism of lead-induced relaxation of pigeon crop smooth muscle. Jour. Pharmacol. Exp. Ther. 234 616-623. 

Sellinger, M., N. Ballatori, and J.L. Boyer. 1991. Mechanism of mercurial inhibition of sodium-coupled alanine uptake in liver plasma membrane vesicles from Raja erinacea. Toxicol. Appl. Pharmacol. 107 369-376. 

Egnell, A.-C., Houston, B. and Boyer, S. (2003) in vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine. The Journal of Pharmacology and Experimental Therapeutics, 305, 1251-1262. 

The spatial separation between the components of the electron transport chain and the site of ATP synthesis was incompatible with simple interpretations of the chemical coupling hypothesis. In 1964, Paul Boyer suggested that conformational changes in components in the electron transport system consequent to electron transfer might be coupled to ATP formation, the conformational coupling hypothesis. No evidence for direct association has been forthcoming but conformational changes in the subunits of the FI particle are now included in the current mechanism for oxidative phosphorylation. 

Paul Boyer United States enzyme mechanism of ATP ... 

For this reason, these alternative routes for isotope combination with enzyme-substrate and/or enzyme-product complexes ensures that raising the [A]/[Q] or [B]/[P] pair will not depress either the A< Q or the B< P exchanges. Fromm, Silverstein, and Boyer conducted a thorough analysis of the equilibrium exchange kinetic behavior of yeast hexokinase, and the data shown in Fig. 2 indicate that there is a random mechanism of substrate addition and product release. 

For patients who do not respond to a specific antidepressant medication or who do not tolerate its side effects, other antidepressants of the same class or different classes (e.g., venlafaxine for a patient treated with a SSRI) can be tried. The few adult studies published thus far suggest that it is more efficacious to switch antidepressant classes than to stay within the same class, because of the probable heterogeneity in underlying depression mechanisms. Also, it has been suggested that severe depressions appear to respond better to antidepressants with both serotonergic and adrenergic properties (e.g., venlafaxine) (Poirier and Boyer, 1999). 

Tantillo C, Ding J, Jacobo-Molina A, Nanni RG, Boyer PL, Hughes SH, et al. Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase implications for mechanisms of drug inhibition and resistance. J Mol Biol 1994 243 369-387. 

For reviews of the stereochemistry and mechanism, see Caro Boyer Lamaty Jaoucn Bull. Soc. Chim. Fr. 1983,11-281-1T303 Boone Ashby Top. Siereochem. 1979, II, 53-95 Wigfield Tetrahedron 1979, 35, 449-462. For a review of stereoselective synthesis of amino alcohols by this method, see Tramontini Synthesis 1982, 605-644. 

---