Mean arterial blood pressure normotensive rats

A similar study of the anti-hypertensive activity of the alkaloids of Kopsia teoi were also carried out which were also prompted by positive results from preliminary screening of alkaloidal extracts. The major aspidofractinine alkaloid kopsingine (191) was found to produce dose-related decreases in mean arterial blood pressure and heart rate in anaesthetized spontaneously hypertensive rats (SHR) which were similar to those elicited in normotensive controls. The same depressor response was shown by the 12-demethoxy derivative (kopsaporine, 192) and the semisynthetic 14,15-dihydto derivative of kopsingine 252, indicating that minor modifications to the basic structure of kopsingine do not significantly alter... 

In Fig. 1 the tremendous decrease in mean arterial blood pressure induced by the potent and A,-selective full agonist N -cyclopentyladenosine (CPA) in an unrestrained, conscious normotensive rat is shown in relation to the blood concentrations of the compound [5],... 

In vivo mean arterial blood pressure in normotensive rats... 

Ko et al. explored how phthalides 20 and 22 mediate the translation from vasodilatation to anti-hypertensive potential. While phthalides 20 and 22 had no effect on the blood pressure of normotensive anesthetized [302] and conscious animals [303], 20 reduced both systolic and diastolic blood pressure in renal hypertensive anesthetized rats [302]. Phthalide 20 also lowered coronary arterial pressure without affecting mean arterial blood pressure in anesthetized dogs [302]. 

Fig. 9. Glucose utilization in the locus coeruleus during hypotension induced by hemorrhage. Upper deoxyglucose autoradiogram prepared from a normotensive rat (mean arterial blood pressure 100 mm Hg). Optical density (and glucose utilization) in the locus coeruleus is similar to adjacent pontine areas. Lower deoxyglucose autoradiograms prepared from a hypotensive rat (mean arterial blood pressure 75 mm Hg). Optical density (and glucose utilization) in the locus coeruleus (LC) is markedly elevated relative to adjacent pontine areas.

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