Matrix network degradation

Silicone networks that form the matrix of the adhesives are not susceptible to degrade or to depolymerize when exposed to a wide range of conditions of temperature and relative humidity. Therefore, the cohesive strength will not change, as... 

The degradation of the matrix in a moist environment strongly dominates the material response properties under temperature, humidity, and stress fatigue tests. The intrinsic moisture sensitivity of the epoxy matrices arises directly from the resin chemical structure, such as the presence of hydrophilic polar and hydrogen grouping, as well as from microscopic defects of the network structure, such as heterogeneous crosslinking densities. 

Other Formulations. Neural networks have been applied to the modeling of pellet formulations to control the release of theophylline [63] and to control the rate of degradation of omeprazole [64]. They have also been applied to the preparation of acrylic microspheres [65] and to model the release of insulin from an implant [66]. In arecent study from Brazil, the release of hydrocortisone from a biodegradable matrix has been successfully modeled [67]. 

The undisturbed organic and the inorganic matrix in a bone form a very stable network which is the reason for the extreme stability of bone. So a mineralized collagen can survive into the archaeological record under certain circumstances and an intact collagen phase can prevent fluorine from penetrating into the sample (Fig. 9). A well-preserved bone may thus show a less-developed profile than a far degraded sample of the same age. 

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