Matrix glycoproteins

Triffitt, J. T., Owen, M. Studies of bone matrix glycoproteins. Incorporation of 1 -14C glucosamine and plasma [14C] glycoprotein into rabbit cortical bone. Biochem. J. 136,125 (1973)... 

Elastic fibers form the network in skin and cardiovascular tissue (elastic arteries) that is associated with elastic recovery. Historically the recovery of skin and vessel wall on removal of mechanical loads at low strains has been attributed to elastic fibers. Elastic fibers are composed of a core of elastin surrounded by microfibrils 10 to 15 nm in diameter composed of a family of glycoproteins recently termed fibrillins. Fibrillins are a family of extracellular matrix glycoproteins (MW about 350,000) containing a large number of cysteine residues (cysteine residues form disulfide crosslinks). Several members of the family have been described. The common molecular features include N and C terminal ends with 47 tandemly repeated epi-... 

Sperm penetrate the zona pellucida only after completion of the acrosome reaction. A similar process occurs in nonmammalian species, where sperm must penetrate the vitelline coat. In abalone this is accomplished by release of lysin, an acrosomal protein that disperses the vitelline coat by a noncatalytic mechanism (Lewis et al., 1982 Shaw et al., 1993). In contrast, the generally accepted model for mammalian sperm penetration of the zona pellucida is the acrosin hypothesis in which proteolysis of zona pellucida matrix glycoproteins by acrosin, the acrosomal serine esterase, plays a trailblazing role in the sperm penetration process (Yanag-... 

Baglia, F. A. and Maul, G. G., Nuclear ribonucleoprotein release and nucleoside triphosphatase activity are inhibited by antibodies directed against one nuclear matrix glycoprotein, Proc. Natl. Acad. Sci. U.S.A., 80[8], 2285, 1983. 

The evidence is increasing that glycosylation of integrins plays important modulatory roles in the function of these molecules. In other studies it appears that the glycosylation of at least one extracellular matrix glycoprotein, namely laminin, is important in cellular adhesion mediated by integrins. So far most information on the role of carbohydrates in integrin-mediated adhesive interactions has been obtained for the fibronectin receptors... 

Mitrovic, N., Dorries, U. and Schachner, M. (1994) Expression of the extracellular matrix glycoprotein tenascin in the somatosensory cortex of the mouse during postnatal development an immuncytochemical and in situ hybridization analysis. J. Neurocytol. 23 364-378. 

Chitosan and its amino acid derivatives (poly D, L-lactic acid) have been explored as an extracellular matrix-like surface to promote cell adhesion and growth [229]. Four kinds of chitosan-amino acid derivatives were prepared to minimize the carbohydrate moieties of cell matrix glycoproteins. 

Garwood, J., Garcion, E., Dobbertin, A., Heck, N., Calco, V., Ffrench-Constant, C., Faissner, A., 2004. The extracellular matrix glycoprotein Tenascin-C is expressed by oligodendrocyte precursor cells and required for the regulation of maturation rate, survival and responsiveness to platelet-derived growth factor. Eur. J. Neurosci. 20, 2524-2540. 

Relatively few studies are available on the effects of vitamin C on synthesis and secretion of matrix molecules apart form collagen and elastin however, in a number of studies occasional mention is found of fibronectin, proteoglycans, bone matrix glycoproteins, and elastin-associated fibrillin (Schwartz et al, 1982 Kielty and Shuttleworth, 1993). 

Structural Collagen, elastin, bone matrix glycoprotein, fibrin... 

Meiners, S. and Mercado, M. L. T. 2003. Fimctional peptide sequences derived from extracellular matrix glycoproteins and their receptors—Strategies to improve neuronal regeneration. Mol Neurobiol 27 177-95. 

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