Matrix effects, industrial chromatography

Hou W, Watters JW, McLeod HL (2004) Simple and rapid docetaxel assay in human plasma by protein precipitation and high-performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B 804 263-267 Schuhmacher J, Zimmer D, Tesche F, Pickard V (2003) Matrix effects during analysis of plasma samples by electrospray and atmospheric pressure chemical ionization mass spectrometry practical approaches to their elimination. Rapid Communications in Mass Spectrometry 17 1950-1957 Shah PW (2001) Guidance for Industry Bioanalytical Method Validation U.S. Department of Health and Human Services, Food and Drug Administration... 

At industrial scale, various chromatographic techniques are available adsorption chromatography, which uses physical binding effects which are dependent on pH or salt concentration affinity chromatography, where a specific binding between a molecule and the matrix is achieved and partition chromatography, where product and impurities move through the bed at different rates. 

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