Matrix-based systems, solute transport

The two-phase motion problem is very stiff, with a wide separation of timescales and a transport matrix which becomes singular as the solution relaxes to its quasi-steady state. The asymptotic analysis presented eliminates the stiffness that is the bane of numerical simulations, affording computational speed-up of 3-4 orders of magnitude over the full system. Building this model into a unit cell simulation code promises huge reductions in computational cost and admits the possibility of performing either full stack-based calculations or doing extensive inverse calculations and parameter estimation. 

It is noteworthy that LOV-based techniques have not only been extensively employed in homogeneous solution-based assays, but have also shown promise in heterogeneous assays because flexible fluid manipulation is also suitable for delivering beads in flow-based manifolds, i.e. precise fluid manipulation by the LOV system and the channel configuration also make it a powerful platform for Bl [22,23]. In combination with the renewable surface concept, Bl has been widely exploited for separation and preconcentration of analytes in the presence of complex matrix components. Most importantly, the automated transport of solid materials in such a system allows their automatic renewal at will and thus provides measurement, packing and perfusion of beads with samples and... 

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