Matrix associated laser desorption ionisation MALDI

Mass spectroscopy [electron ionisation (El), chemical ionisation (Cl), electrospray ionisation (ESI), fast atom bombardment (FAB), matrix-associated laser desorption ionisation (MALDI), inductively coupled plasma-mass spectrmetry (ICP-MS, cf and ), etc]... 

Figure 9.5 Schematic of Matrix Assisted Laser Desorption Ionisation (MALDI). The laser is fired at the sample analyte of interest admixed with a crystalline matrix that readily absorbs laser energy and allows the sputtering of analyte into the vapour phase in association with matrix molecules of solvation. Desolvation and proton transfer leads to naked molecular ion species, ready for mass analysis.

Szabados F, Becker K, von Eiflf C, Kaase M, Gatermann S. The matrix-assisted laser desorption/ ionisation time-of-flight mass spectrometry (MALDI-TOF MS)-based protein peaks of 4448 and 5302 Da are not associated with the presence of Panton-Valentine leukocidin. Int J Med Microbiol. 2011 301(l) 58-63. doi 10.1016/j.ijmm.2010.05.005. 

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