Mathies, Richard

Hashimoto M, Barany F, Xu F, Soper SA (2007) Analyst 132 913 Simpson PC, Woolley AT, Mathies RA (1998) Biomed Microdevices 1 7 Belgrader P, Smith JK, Weedn VW, Northmp MA (1998) J Forensic Sci 43 315 Northrup MA, Benett B, Hadley D, Landre P, Lehew S, Richards J, Stratton P (1998) Anal Chem 70 918... 

Physical or instrumental methods were extensively developed in the twentieth century and are gradually replacing classical methods. In Principles of Instrumental Analysis, three American chemists, Douglas Skoog, F. James Holler, and Timothy Nieman, detail many instrumental methods that use highly complex and often costly machines to determine the identity and concentration of analytes. While these methods often are not as accurate and precise as classical methods, they require much less sample and can determine concentrations much less than 0.1 percent. In fact, Richard Mathies, professor at the University of California at Berkeley, and coworkers recendy described methods that can determine the presence of one molecule In addition, instrumental methods often produce results more rapidly than chemical methods and are the methods of choice when a very large number of samples of the same kind have to be analyzed repetitiously, as in blood analyses. 

August H. Maki (25), Department of Chemistry, University of Caiifornia, Davis, Davis, California 95616 Richard A. Mathies (16), Department of Chemistry, University of California, Berkeley, Berkeley, California 94720 SioBHAN M. Muck (24), Department of Chemistry, Sinsheimer Laboratories,... 

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