Mast cell chymase

A Sail, R Matsumoto, HP McNeil, M Karplus, RL Stevens. Three-dimensional models of four mouse mast cell chymases. Identification of proteoglycan-bmdmg regions and protease-specific antigenic epitopes. I Biol Chem 268 9023-9034, 1933. 

Through an indirect mechanism tryptase also activates coUagenase (Gruber ettU., 1989), while mast cell chymase has been implicated in matrix degradation (Briggman et /., 1984). 

Mizutani, H., Schechter, N.M., Lazarus, G.S., Black, RA. and Kupper, T.S. (1991). Rapid and specific conversion of precursor interleukin 1 beta (11 1 beta) to an active lL-1 species by human mast cell chymase. J. Exp. Med. 174, 821-825. 

Sommerhoff, C.P., Caughey, G.H., Finkbeiner, W.E., Lazarus, S.C., Basbaum, C.B. and Nadel, J.A. (1989). Mast cell chymase. A potent secretagogue for airway gland serous cells. J. Immunol. 142, 2450-2456. 

The action of VIP at its receptor is competitive with its degradation by proteases found in the microenvironment of the receptor. VIP is known to be a favored substrate for NEP, mast cell tryptase and mast cell chymase, all of which are active at the neutral pH likely to prevail in the extracellular microenvironment. Recombinant human... 

Mast cell chymase potentiates H-induced wheal... 

Vartio, T., Seppa, H. and Vaheri, A. (1981). Susceptibility of soluble and matrix fibronectin to degradation by tissue pro-teinases, mast cell chymase and cathepsin G. J. Biol. Chem. 256, 471-477. 

The major sites of the peptide metabolism are the lungs, followed by the liver and the kidneys. The peptide is degraded by neutral endopeptidase, mast cell tryp-tase and mast cell chymase [17]. 

Gallwitz M, Reimer JM, Heilman L. Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution. Immunogenetics. 2006 58 655-69. 

Lee M, Calabresi L, Chiesa G, Franceschini G, Kovanen FT. Mast cell chymase degrades apoE and apoA-n in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol eSiax.Arterioscler Thromb Vase Biol2002 22 1475-1481. 

Taipale J, Lohi J, Saarinen J, Kovanen PT, Keski OJ. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells. JBiol Chem 1995 270 4689-4696. 

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