Marine macrolide cytotoxic activity

Bryostatins. The bryostatins are a group of cytotoxic marine macrolides, isolated from invertebrate filter feeders, that exhibit promising anticancer activity (Scheme 9-36). Two completed total syntheses of the bryostatins have demonstrated the versatility and power of aldol reactions in the concise assembly of complex polyketides. 

Amphidinoildes. A family of marine macrolides with potent antineoplastic activity. A. are produced by sym-biontic microalgae Amphidinium sp., dinoflagellates, harvested from the inner tissue of the host Okinawan flatworms Amphiscolops sp.. A. show cytotoxic and... 

Marine sponges of the genus Haliclona contain a diverse array of active secondary metabolites, including highly potent cytotoxic macrolides, e g., halichondrin and related compounds, Fig. (56) [468], and salicylihalamides A and B, Fig. (57) [469], New macrolides chemically related to salicylihalamides, apicularens A and B, were recently isolated from the myxobacteria Chondromyces sp. [470], From marine bacteria, other cytotoxic macrolides have been isolated, such as octalactin A, Fig. (58) and B, which have been shown as a cell cycle-specific anticancer drug [471], and swinholide, Fig. (59), isolated from symbiotic cyanobacteria with the marine sponge Theonella swinhoei [472]. 

Femandez-Chimeno, I. R., Canedo, L., Espliego, R, Gravalos, D., De La Calle, F, Femandez-Puentes, J. L., and Romeo, F. (2000). IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. 53,474-478. 

Kobayashi, M., Kawazoe, K., Okamoto, T., Sasaki, T, and Kitagawa, I. (1994). Marine natural products. XXXI. Structure-activity correlation of a potent cytotoxic dimeric macrolide swinholide A, from the Okinawan marine sponge Theonella swinhoei, and its isomers. Chem. Pharm. Bull. 42, 19-26. 

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