Marine bioactive compounds synthesis

POLYCYCLIC AMINE ALKALOIDS (3-ALKYLPIPERIDBVE ALKALOIDS) - NOVEL MARINE BIOACTIVE COMPOUNDS STRUCTURE, SYNTHESIS AND BIOCHEMICAL ASPECTS... 

Rodriguez, J. (2000) Polycyclic amine alkaloids (3-alkylpiperidine alkaloids) novel marine bioactive compounds structures, synthesis and biochemical aspects, in Studies in Natural Products Chemistry, vol. 24 (ed. Atta-ur-Rahman), Elsevier, pp. 573—681. 

Natural Product Chemistry continues to present exciting opportunities for medicinal chemists to discover new bioactive compounds against various diseases. Even in cases where the structures are too complex to be obtained on a large scale by synthesis, the interest is often focussed on those portions of the stnictures which are responsible for the biological activity and which can serve as simpler pharmacophores for synthesis and study of structure-activity relationships. The enormous structural diversity offered by natural products of terrestrial and marine origin therefore offers a vast resource to medicinal chemists in search for new bioactivity profiles or mechanisms of actions. 

Total synthesis of bioactive tricyclic marine alkaloids with A-heterocyclic fragments, lepadiformine, and related compounds 03BCJ2059. 

Besides heteroaromatic compounds also electron-rich aromatic compounds like aniline or naphthol derivatives have been employed in organocatalytic Friedel-Crafts reactions (267, 268). Kim et al. demonstrated this in the synthesis of (+)-curcuphenol (294) (267), a bioactive sesquiterpene phenol isolated from the marine... 

Finally, a microwave-assisted Minisci reaction was successfully applied to a two-step method for the synthesis of the marine alkaloid fascaplysin (10), a compound which exhibits a broad range of bioactivity (Scheme 5) [15]. 

Kibayashi, C., Aoyagi, S., and Abe, H. (2003) Total synthesis of bioactive tricyclic marine alkaloids, lepadiformine and related compounds. Bull. Chem. Soc. Jpn, 76, 2059-2074. 

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