Maprotiline dosage

Mild to moderate depression An initial dose of 75 mg/day is suggested for outpatients. In some patients, especially the elderly, an initial dose of 25 mg/day may be used. Because of the long half-life of maprotiline, maintain initial dosage for 2 weeks. Gradually increase the dosage in 25 mg increments, as required and tolerated. Most patients respond to a dose of 150 mg/day, but doses as high as 225 mg/day may be required. 

Maprotiline, a tetracyclic antidepressant, repeatedly induced hypoglycemia in a 39-year-old woman with type 1 diabetes, even when the insulin dosage was reduced from 20 U/day to 4-10 U/day. Maprotiline seems to prolong the half-life of insulin. A glucagon... 

The interaction between clonidine and the trieyelics is established and clinically important. The incidence is uncertain but it is not seen in all patients. Avoid concurrent use unless the effects can be monitored. Increasing the dosage of clonidine may possibly be effective. The clonidine dosage was apparently successfully titrated in 10 out of 11 hypertensive patients already on amitriptyline or imipramine. Only clomipramine, desipramine and imipramine have been implieated so far, but other tricyclics would be expected to behave similarly (amitriptyline, nortriptyline and protriptyline have been shown to interact in animals ). The tetracyclic antidepressants maprotiline and mianserin do not generally appear to interact with clonidine. The isolated case of hypotension with trazodone is of unknown general importance. 

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