Manufacturing technologies physicochemical characterization

The field of co-crystals has elicited significant interest in the pharmaceutical industry recently with the potential to utilize this technology as means of enhancing physicochemical properties such as solubility and dissolution in addition to enhancements to particle properties that could aid drug product development,. e.g. improving both chemical and physical stability and indeed as a method to induce crystallization of materials that traditionally would have been isolated as an oil or an amorphous material. There is also considerable ongoing debate as to the theoretical definition of a co-crystal, how a co-crystal can be reliably synthesized, manufactured and characterized, coupled with the intellectual properties ramifications therein. This presentation will outline some of our recent research efforts (in-house external) into the synthesis of co-crystals, and will outline different techniques that can be utilized to characterize co-crystals. 

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