Manoalide from marine sponge

De Silva, E. D., and Scheuer, P. J., Manoalide, an antibiotic sesterterpenoid from the marine sponge Lujfariella variabilis (Polejaeff), Tetrahedron Lett., 21, 1611, 1980. 

Problem 29.1 2 Manoalide, a sesterterpene isolated from the Pacific marine sponge Luffariella veriabills by Scheuer and co-workers at the University of Hawai i at Manoa, has anti-inflammatory, analgesic, and antifungal properties. Find the isoprene units in manoalide. 

However, clinical studies on marine metabolites are often hampered by insufficient supply of material, as it was reported for dolastatin 10 from the sea hare Dolabella auricularia [107]. In the case of manoalide, obtained from the sponge Luffariella variabilis, it remains open whether its use will be restricted to an application in studying inflammatory processes on the cell level or whether it... 

Cyclohexane sesterterpenes are formally derived from 3,7,11,15,19-pentamethyl-icosane by connection of the C-14-C-19 bond. A few representatives are found in various marine sponges. The lactone (-)-manoalide isolated from the sponge Luf-... 

Gauvin-Bialecki, A., Aknin, M., and Smadja, J. (2008) 24-0-Ethylmanoalide, a manoalide-related sesterterpene from the marine sponge Luffariella cf variabilis. Molecules, 13, 3184-3191. 

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