Phosphotransferase systems mannose

Cochu, A., Vadeboncoeur, C., Moineau, S., and Frenette, M. (2003) Genetic and biochemical characterization of the phosphoenolpyruvaterglucose/mannose phosphotransferase system of Streptococcus thermophilus. Appl Environ... 

Kjos, M., Nes, I.F., and Diep, D.B., 2009. Class II one-peptide bacteriocins target a phylogenetically defined subgroup of mannose phosphotransferase systems on sensitive cells. Microbiology 155, 2949-2961. 

The Enzymes II (E-IIs) of the phosphoenolpyruvate (P-enolpyruvate)-dependent phosphotransferase system (PTS) are carbohydrate transporters found only in prokaryotes. They not only transport hexoses and hexitols, but also pentitols and disaccharides. The PTS substrates are listed in Table I. The abbreviations used (as superscripts) throughout the text for these substrates are as follows Bgl, jS-gluco-side Cel, cellobiose Fru, fructose Glc, glucose Gut, glucitol Lac, lactose Man, mannose Mtl, mannitol Nag, iV-acetylglucosamine Scr, sucrose Sor, sorbose Xtl, xylitol. 

Grenier, F.C. Waygood, E.B. Saier, M.H. Bacterial phosphotransferase system regulation of the glucose and mannose enzymes II by sulfhydryl oxidation. Biochemistry, 24, 4872-4876 (1985)... 

A.6.1.7 The glucose/mannose/2-deoxyglucose/ fructose phosphotransferase systems, ManLMN Strep, thermophilus Cochu et al. 2003... 

Ramnath, M., Beukes, M., Tamura, K., and Hastings, J.W. (2000). Absence of a putative mannose-specific phosphotransferase system enzyme IIAB component in a leucocin A-resistant strain of Listeria monocytogenes, as shown by two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Appl Environ Microbiol 66, 3098-3101. 

In this chapter, we indicate that the metabolic error (i.e., deficiency of phosphotransferase activity in I-cell disease) gives rise to a secondary phenotype of generalized diminished lysosomal enzyme activity. What other metabolic defects in the mannose 6-phosphate-mediated uptake system could result in such a phenotype, and how would you confirm the defect ... 

The chemotactic receptors to glucose, fructose, mannose and certain other sugars are insensitive to osmotic shock (Table 4.1) and have been shown to be integral parts of the cytoplasmic membrane. These membrane-associated receptors have been shown to be identical with enzymes II, the substrate-specific components of phosphotransferase transport (the PEP system). The essential event during sugar translocation using the PEP system is the phosphoenolpyruvate-dependent phosphorylation of the... 

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